Chemical Structure: MIK665
CAS No.: 1799631-75-6
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MIK665(MIK 665, S 64315, S64315)
Catalog No.: URK-V595聽聽Only Used For Lab.
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
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Biological Activity
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1.
Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
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Physicochemical Properties
M.Wt875.413
FormulaC47H44ClFN6O6S
CAS No.1799631-75-6
StorageSolide Powder
-20 掳C 3years;
4掳C 2yearsIn Solvent
-80掳C 6 Months
-20掳C 1 Months
Solubility10 mM in DMSO
Chemical Name(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid
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References
1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098.
URK-V595_COA
URK-V595_SDS
URK-V595_TDS
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